Click here to sign in with or

by Zhang Nannan, Chinese Academy of Sciences

A research team led by Prof. Zhao Gang from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, collaborating with Prof. Liu Huilan from the First Affiliated Hospital of USTC, has achieved high-performance cryopreservation of living cells using synergetic ice inhibition effects of two-dimensional (2D) titanium carbide (Ti3C2Tx) MXene nanosheet.

This achievement expands the application of efficient cryopreservation based on physical fields. Relevant results were published in ACS Nano.

Ice formation, growth, and injury are one of the main challenges for successful cryopreservation of cells, tissues, organs, and biocomposites like living cell constructs and cultures. A deep understanding of ice crystal formation and the development of effective methods or materials to control ice formation and growth has a profound influence on fundamental research and practical applications.

Functional nanomaterials have become a research hotspot for ice inhibition materials. However, most studies only focus on the molecular ice suppression effect of nanomaterials. Studies of synergetic ice inhibition effects, such as combination with photothermal or magnetothermal effects, are still rare.

In view of this, the researchers investigated synergetic ice suppression effects of 2D Ti3C2Tx MXene nanosheets, including their regulating function of ice crystals morphology, growth, and thawing.

According to the researchers, in the cooling process, Ti3C2Tx can inhibit the sharp edge morphology of ice crystals and reduce direct damage. In the thawing stage, the high-efficiency photothermal conversion property of Ti3C2Tx facilitates rapid ice melting, thus reducing the devitrification and ice recrystallization.

High-performance cryopreservation of stem-cell-laden hydrogel constructs was realized with the use of the synergistic ice-suppressing effect of these 2D MXene nanosheets. Explore further Organ storage a step closer with cryopreservation discovery More information: Yuan Cao et al, Inhibition Effect of Ti3C2Tx MXene on Ice Crystals Combined with Laser-Mediated Heating Facilitates High-Performance Cryopreservation, ACS Nano (2022). DOI: 10.1021/acsnano.1c10221 Journal information: ACS Nano

More from Physics Forums | Science Articles, Homework Help, Discussion

Use this form if you have come across a typo, inaccuracy or would like to send an edit request for the content on this page. For general inquiries, please use our contact form. For general feedback, use the public comments section below (please adhere to guidelines).

Please select the most appropriate category to facilitate processing of your request

Thank you for taking time to provide your feedback to the editors.

Your feedback is important to us. However, we do not guarantee individual replies due to the high volume of messages.

Your email address is used only to let the recipient know who sent the email. Neither your address nor the recipient's address will be used for any other purpose. The information you enter will appear in your e-mail message and is not retained by Phys.org in any form.

Get weekly and/or daily updates delivered to your inbox. You can unsubscribe at any time and we'll never share your details to third parties.

Medical research advances and health news

The latest engineering, electronics and technology advances

The most comprehensive sci-tech news coverage on the web

This site uses cookies to assist with navigation, analyse your use of our services, collect data for ads personalisation and provide content from third parties. By using our site, you acknowledge that you have read and understand our Privacy Policy and Terms of Use.